D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-
D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-
CAS: 693790-96-4
Molecular Formula: C26H23N3O3
D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- - Names and Identifiers
| Name | D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- |
| Synonyms | BAY 73-1449 D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- |
| CAS | 693790-96-4 |
D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- - Physico-chemical Properties
| Molecular Formula | C26H23N3O3 |
| Molar Mass | 425.48 |
| Density | 1.273±0.06 g/cm3(Predicted) |
| Boling Point | 700.4±60.0 °C(Predicted) |
| pKa | 3.35±0.10(Predicted) |
| In vivo study | BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats. BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats. BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats. Animal Model: Male Wistar rats (250-350 g) are ligated portal vein Dosage: 0.1, 1 mg/kg Administration: A single i.v. Result: Significantly reduced shunt flow without affecting mesenteric flow. |
D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- - Reference Information
| biological activity | BAY 73-1449 is an antagonist of selective prostacyclin receptor (prostacyclin receptor, IP), which is used in human HEL cells and rat DRG. The cAMP analysis has a high titer (IC50 value less than 0.1 nM). BAY 73-1449 can be used for the study of lowering blood pressure. |
| target | IP Receptor <0.1 nM (IC 50 ) |
| in vivo study | BAY 73-1449 (0.1-1 mg/kg; I. v.) does not significantly reduce mesenteric flow, but significantly reduces splenic shunvessel outflow in rats. BAY 73-1449 (1-5 mg/kg, S. c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats. BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats. Animal Model: Male Wistar Rats (250-350g) are ligated portal vein Dosage: 0.1, 1 mg/kg Administration: A single I. v. Result: significantly reduced shoot flow without affecting mesenteric flow. |
| Animal Model: | Male Wistar rats (250-350 g) are ligated portal vein |
| Dosage: | 0.1, 1 mg/kg |
| Administration: | A single i.v. |
| Result: | Significantly reduced shunt flow without affecting mesenteric flow. |
Last Update：2024-04-09 21:49:45
![D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-](http://res.chembk.com/assets/images/structure/693790-96-4.gif)